Sulfuric Acid → 7-Chloro-4-methyl-8-nitroisoquinoline

HRID 223145Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 223145
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[N+:18]([O-])([O-:20])=[O:19].[K+]>>[Cl:1][C:2]1[C:11]([N+:18]([O-:20])=[O:19])=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 1118Sulfuric Acid2×HCID 24434Potassium NitrateHCID 205232237-Chloro-4-methylisoquinoline

Produkt 1

HCID 205232187-Chloro-4-methyl-8-nitroisoquinoline

Versuchsvorschrift

A mixture of 17.7 g. (0.1 mole) of 7-chloro-4-methylisoquinoline and 100 ml. of concentrated sulfuric acid is treated with 10 g. (0.1 mole) of potassium nitrate dissolved in 150 ml. of concentrated sulfuric acid. The mixture is stirred for one hour, quenched on ice, made alkaline with ammonium hydroxide and filtered to yield 7-chloro-4-methyl-8-nitroisoquinoline.

Aufarbeitung

  1. additionA mixture of 17.7 g
  2. customquenched on ice
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-153a648d1b2f46eea8d8e5555ee8287b
Quelldatensatz
uspto-grants-1982_10
Patentnummer
US04352809

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