HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-methoxy-7-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reactant | 7-[3-(methanesulfonyloxy)propoxy]-6-methoxy-2H-1-benzopyran-2-one | HCID 19927657 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 6-methoxy-7-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one | HCID 19927737 | 73% |
Reaction Steps
Method B (20 h at 60° C.); starting materials: 7-[3-(methanesulfonyloxy)propoxy]-6-methoxy-2H-1-benzopyran-2-one (example 68) and 4-phenylpiperidine; yield 73%; fusion point 97°-99° C. (from isopropanol). Hydrochloride: method G; yield 93%; fusion point 198°-200° C. (from isopropanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-074ad729d54a49d0a78cc3cd3d689108 |
| Source note | uspto-grants-1995_06 |