Ammonia → HCID 135574542, compound

HRID 2231508Notes

Reaction equation

HRID 2231508 reaction equation
Br.[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[OH:13])[CH:9]=[N:8][CH:7]=[CH:6]2.N>O>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[OH:13])[CH:9]=[N:8][CH:7]=[CH:6]2

Participants

4

Reactant 2

HCID 222AmmoniaHCID 135736659113884-76-7

Product 1

HCID 135574542HCID 135574542, compoundYield 93.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

9.78 g (40.4 mol) of 6,7-dihydroxyisoquinoline hydrobromide was dissolved under heating in 400 ml of water and treated with 1 g of active carbon. The filtrate thereby obtained was adjusted to pH8.0 with a 8% aqueous ammonia, and the mixture was stirred under cooling with ice. The crystals formed were collected by filtration. They were washed with water and acetone and dried to obtain 6.08 g (yield: 93.4%) of the above identified compound.

Workup

  1. additiontreated with 1 g of active carbon
  2. customThe filtrate thereby obtained
  3. temperatureunder cooling with ice
  4. customThe crystals formed
  5. filtrationwere collected by filtration
  6. washThey were washed with water and acetone
  7. customdried
  8. customto obtain 6.08 g (yield: 93.4%) of the

Sources & evidence

ORD record
ord-09427092f907430f91c69c908c597a81
Source dataset
uspto-grants-1988_11
Patent number
US04782155

Reaction notes

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