Ammonia → HCID 135409288, compound

Participants

Reaction Steps

4-Chloro-2-methylsulfonyl-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine reacted sequentially with sodium allyloxide and liquid ammonia and deblocked by hydrogenation in the presence of a catalyst provides 2-amino-7-β-D-arabinofuranosyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one. Treatment with phosphoryl chloride and triethyl phosphate provides the corresponding 5'-phosphate compound.

Provenance & Evidence