Phenobarbital → HCID 19975187, compound

Participants

Reaction Steps

The DppE amide of 1-(4-carboxybutyl)-5-ethyl-5-phenyl barbituric acid (DPPE-phenobarbital) was prepared as outlined in FIG. 2. The sodium salt of phenobarbital (compound A) (2 mmoles) formed by treating phenobarbital with sodium hydroxide was reacted with the methyl ester of 5-bromovaleric acid (2.200 mmoles) in 5 ml of N,N-dimethyl formamide, for 4 hrs at 96° C., to form the methyl ester of 1-(4-carboxybutyl)-5-ethyl-5-phenyl barbiturate (compound B). The product was purified by column chromatography at a yield of about 77%.

Provenance & Evidence