反应详情

2-Anilino-4,6-dimethylpyrimidine hydrochloride (100 g) was suspended in toluene (1200 ml). A slow stream of phosgene was passed through this over 5.5 hours at 108° (bath temperature of 120°) and then stirred for a further hour at the same temperature. After standing overnight, c. 300 ml of toluene was distilled at a bath temperature of 150°. It was then evaporated under reduced pressure. The oily residue was extracted twice with hexane (1000 ml) and the solution concentrated under reduced pressure. After a period of time crystals formed and these were separated to give N-(4,6-dimethylpyrimidin-2-yl)-N-phenylcarbamoyl chloride. This was shown by thin layer chromatography to be a uniform product, which was used without further purification.

1. customover 5.5 hours
2. customat 108°
3. custom(bath temperature of 120°)
4. distillation300 ml of toluene was distilled at a bath temperature of 150°
5. customIt was then evaporated under reduced pressure
6. extractionThe oily residue was extracted twice with hexane (1000 ml)
7. concentrationthe solution concentrated under reduced pressure
8. customAfter a period of time crystals formed
9. customthese were separated