反应详情

2-Anilino-4,6-dimethylpyrimidine (10 g) was added to formic-acetic anhydride (prepared from formic acid (5 ml) and acetic anydride (12 ml)) and the mixture heated gently to 40° to give a clear solution. After standing for 4 days, a crystalline solid separated and toluene was added to give a clear solution again. The mixture was evaporated to dryness, more toluene added and reevaporated. The product was recrystallised from ethyl acetate/light petroleum to give N-(4,6-dimethylpyrimidin-2-yl)-formanilide, m.p. 134°-5°. (Compound 3).

1. temperaturethe mixture heated gently to 40°
2. customto give a clear solution
3. customa crystalline solid separated
4. additiontoluene was added
5. customto give a clear solution again
6. customThe mixture was evaporated to dryness, more toluene
7. additionadded
8. customreevaporated
9. customThe product was recrystallised from ethyl acetate/light petroleum