Sodium Carbonate → N-[[2-Amino-5-(2,4-dimethyl-1H-imidazol-1-yl)phenyl]methyl]glycine methyl ester

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A mixture of ethyl N-trifluoroacetyl-N-(2-amino-5-[2,4-dimethylimidazol-1-yl]benzyl)glycinate (1.4 g) and anhydrous sodium carbonate (0.74 g) in methanol (20 cm3) was heated under reflux for 3 hours. The cooled solution was evaporaed to dryness in vacuo and the residue was partitioned between chloroform (50 cm3) and water (10 cm3). The aqueous phase was re-extracted with chloroform (2×25 cm3) and the combined and dried (MgSO4) organic extracts were evaporated to give an oil which was chromatographed on silica (Merck "MK 60.9385" [Trade mark]), eluting with ethyl acetate:methanol, 9:1. Combination and evaporation of the appropriate fractions afforded the title compound as an oil (0.41 g), used directly.

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