Leukotriene C4 → Leukotriene C4

HRID 2231669Notes

Reaction equation

HRID 2231669 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5]/[CH:6]=[CH:7]\[CH2:8]/[CH:9]=[CH:10]\[CH:11]=[CH:12]\[CH:13]=[CH:14]\[C@@H:15]([S:24][CH2:25][C@H:26]([NH:34][C:35]([CH2:37][CH2:38][C@H:39]([NH2:43])[C:40]([OH:42])=[O:41])=[O:36])[C:27]([NH:29][CH2:30][C:31]([OH:33])=[O:32])=[O:28])[C@@H:16]([OH:23])[CH2:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21].[CH3:44][CH2:45][CH2:46][CH2:47][CH2:48]/[CH:49]=[CH:50]\[CH2:51]/[CH:52]=[CH:53]\[CH:54]=[CH:55]\[CH:56]=[CH:57]\[C@@H:58]([S:67][CH2:68][CH:69]([NH2:77])[C:70]([NH:72][CH2:73][C:74]([OH:76])=[O:75])=[O:71])[C@@H:59]([OH:66])[CH2:60][CH2:61][CH2:62][C:63]([OH:65])=[O:64]>>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5]/[CH:6]=[CH:7]\[CH2:8]/[CH:9]=[CH:10]\[CH:11]=[CH:12]\[CH:13]=[CH:14]\[C@@H:15]([S:24][CH2:25][C@H:26]([NH:34][C:35]([CH2:37][CH2:38][C@H:39]([NH2:43])[C:40]([OH:42])=[O:41])=[O:36])[C:27]([NH:29][CH2:30][C:31]([OH:33])=[O:32])=[O:28])[C@@H:16]([OH:23])[CH2:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21].[CH3:44][CH2:45][CH2:46][CH2:47][CH2:48]/[CH:49]=[CH:50]\[CH2:51]/[CH:52]=[CH:53]\[CH:54]=[CH:55]\[CH:56]=[CH:57]\[C@@H:58]([S:67][CH2:68][CH:69]([NH2:77])[C:70]([NH:72][CH2:73][C:74]([OH:76])=[O:75])=[O:71])[C@@H:59]([OH:66])[CH2:60][CH2:61][CH2:62][C:63]([OH:65])=[O:64].[NH2:43][CH2:39][CH2:38][C:37]1[N:72]=[CH:26][NH:34][CH:35]=1

Participants

5

Reactant 2

HCID 5280493Leukotriene C4HCID 6435286(3H)Ltd4

Product 3

HCID 5280493Leukotriene C4HCID 6435286(3H)Ltd4HCID 178419017HCID 178419017, compound

Procedure

Antagonisms for LTC4 and LTD4 were determined in isolated guinea-pig trachea prepared as spiral strip. Tracheal preparations were suspended under 1 g tension in 10 ml organ baths and they were incubated for 1 hr prior to use. Contractile responses to LTC4 (2×10-8 g/ml) and LTD4 (2×10-8 g/ml) were obtained after the maximal response to histamine (10-4M). Test compounds dissolved in 100% dimethyl sulfoxide were added to the organ baths (final concentration of 10-5 g/ml or 10-6 g/ml) 5 min prior to LTC4 and LTD4 addition, and then contractile responses to LTC4 and LTD4 were compared with those of control which was obtained from a paired trachea in the absence of test compounds. LTC4 - and LTD4 -induced contractions were expressed as a percentage of the maximal response to histamine. The antagonism was determined as follows:

Workup

  1. customprepared as spiral strip

Sources & evidence

ORD record
ord-21b06084420c4bc8bf991e74e3b9b60b
Source dataset
uspto-grants-1988_11
Patent number
US04783462

Reaction notes

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