2-tert-butyl-5-chloro-4-methylpyridazin-3-(2H)-one → 2-t-butyl-5-chloro-4-ethyl-3(2H)-pyridazinone

HRID 2231677Notes

Reaction equation

HRID 2231677 reaction equation
CC1C(=O)N(C(C)(C)C)N=CC=1Cl.[CH2:14]([C:17]1[C:18](=[O:28])[N:19]([C:24]([CH3:27])([CH3:26])[CH3:25])[N:20]=[CH:21][C:22]=1[Cl:23])[CH2:15]C.C(C1C(=O)N(C(C)(C)C)N=CC=1Cl)CCC.C(C1C(=O)N(C(C)(C)C)N=CC=1Cl)CCCC>>[CH2:14]([C:17]1[C:18](=[O:28])[N:19]([C:24]([CH3:27])([CH3:26])[CH3:25])[N:20]=[CH:21][C:22]=1[Cl:23])[CH3:15]

Participants

5

Reactant 4

HCID 138222642-tert-butyl-5-chloro-4-methylpyridazin-3-(2H)-oneHCID 19903158HCID 19903158, compoundHCID 212854754-n-butyl-5-chloro-2-t-butyl-3(2H)pyridazinoneHCID 212854934-n-pentyl-5-chloro-2-t-butyl-3(2H)pyridazinone

Product 1

HCID 138250102-t-butyl-5-chloro-4-ethyl-3(2H)-pyridazinone

Procedure

In the same manner as above, the following compounds were prepared from the corresponding 2-alkyl-4,5-dichloro-3(2H)pyridazinones and alkyl magnesium halides: 4-Methyl-5-chloro-2-t-butyl-3(2H) pyridazinone [oily substance, boiling point: 60°-62° C. (0.22 mmHg)], 4-n-propyl-5-chloro-2-t-butyl-3(2H) pyridazinone (oily substance), 4-n-butyl-5-chloro-2-t-butyl-3(2H)pyridazinone (only substance) and 4-n-pentyl-5-chloro-2-t-butyl-3(2H)pyridazinone (oily substance).

Sources & evidence

ORD record
ord-a3ffa75dbdd34aa28e977d83e75f4bc0
Source dataset
uspto-grants-1988_11
Patent number
US04783462

Reaction notes

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