10-Acetamido-10-(3-chlorophenyl)-2,3,4,10-tetrahydropyrimido[1,2-a]indole → 10-Amino-10-(3-chlorophenyl)-2,3,4,10-tetrahydropyrimido[1,2-a]indole

Participants

Reaction Steps

A solution of the product of Example 1 (2.48 g) in hydrochloric acid 36% w/w (10 ml) was heated at 120° with stirring for 21/2 hours, cooled to room temperature, diluted with H2O (50 ml), washed with ethyl acetate (3×50 ml), basified with 33% aqueous ammonia and extracted with chloroform (3×100 ml). The extracts were washed with brine (100 ml), dried (MgSO4) and evaporated in vacuo. The oil was dissolved in methanol (10 ml), acidified with ethereal HCl, and evaporated in vacuo to give a solid which was triturated with ether (3×10 ml) to give the title compound as the hydrochloride (1.83 g) as colourless crystals, m.p. 274°-276° (dec.).

Provenance & Evidence