Imidazole → HCID 20523185, compound

Participants

Reaction Steps

Dissolve imidazole (25.8 gms., 380 mmols) in water (100 ml.) and add 7-chloro-3-(dimethylaminomethyl)thiochroman-4-one hydrochloride (11.1 gms., 38.0 mmols). Stir the reaction mixture overnight at room temperature, then add water (1 liter) and extract with chloroform (500 ml.). Wash the chloroform solution with 2 liter portions of water, dry over anhydrous magnesium sulfate, filter and evaporate in vacuo to a residue. Chromatograph the residue on a silica gel column eluting with chloroform. Combine the like eluates as determined by thin layer chromatography and evaporate in vacuo to a residue comprising 7-chloro-3-(1'-imidazolylmethyl)thiochroman-4-one. Further purify by recrystallization from chloroform/hexane, m.p. 104°-105° C.

Provenance & Evidence