Sodium borohydride → HCID 20523155, compound

Participants

Reaction Steps

Dissolve 5-chloro-2-(1'-imidazolylmethyl)coumaran-3-one (10 gms., 21 mmols.) in methanol (100 ml.), cool the solution to 0°-5° C. and add sodium borohydride (1.0 gms., 26.4 mmols.). Stir the reaction mixture overnight at room temperature and evaporate the methanol in vacuo. Add water (200 ml.) to the resultant residue and stir for 30 minutes. Filter and wash the resultant residue with water to give 5-chloro-2,3-dihydro-3-hydroxy-2-(1'-imidazolylmethyl)benzo(b)furan.

Provenance & Evidence