HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium borohydride → 2-Fluoro-4-(hydroxymethyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium borohydride | HCID 4148881 | — |
| Reactant | Ethyl 4-cyano-3-fluorobenzoate | HCID 21284546 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Fluoro-4-(hydroxymethyl)benzonitrile | HCID 11829631 | — |
Reaction Steps
40 g of ethyl 4-cyano-3-fluorobenzoate in 40 ml of THF are added dropwise to a solution of 8 g of LiBH4 in 120 ml of THF. In the course of this, the reaction mixture comes to the boil. After one hour it is acidified with 2NHCl and worked up in a customary manner. 3-Fluoro-4-cyanobenzyl alcohol, m.p. 70°-72° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04784471 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-c8861f08df674d4b950967272d1f04b9 |
| Source note | uspto-grants-1988_11 |