Nitric Acid → HCID 616538, compound

HRID 223182Notes

Reaction equation

HRID 223182 reaction equation
[CH3:1][N:2]1[C:8](=[O:9])[C:7]2[CH:10]=[CH:11][CH:12]=[CH:13][C:6]=2[NH:5][C:4](=[O:14])[CH2:3]1.[N+:15]([O-])([OH:17])=[O:16]>>[CH3:1][N:2]1[C:8](=[O:9])[C:7]2[CH:10]=[C:11]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:13][C:6]=2[NH:5][C:4](=[O:14])[CH2:3]1

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 37255754-methyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2,5-dione

Product 1

HCID 616538HCID 616538, compound

Procedure

300 ml of 89 percent nitric acid are treated portionwise at room temperature over a period of 35 minutes with 94.5 g (496.8 mmol) of 3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione. The mixture is stirred at room temperature for 18 hours and poured into 3.5 l of ice-water. The precipitated material is filtered off under suction, washed with water and dried at 70° in vacuo. There is obtained 3,4-dihydro-4-methyl-7-nitro-2H-1,4-benzodiazepine-2,5(1H)-dione of melting point 252°-253°.

Workup

  1. filtrationThe precipitated material is filtered off under suction
  2. washwashed with water
  3. customdried at 70° in vacuo

Sources & evidence

ORD record
ord-6a9dc184d41445839ade511bc5464387
Source dataset
uspto-grants-1982_10
Patent number
US04352815

Reaction notes

Loading…