Acetyl chloride → HCID 70417938, compound

Participants

Reaction Conditions

Reaction Steps

To 2.67 g (0.01 mol) of trans-4-(4-hydroxyphenyl)-3-phenyl-2-piperidone 27 dissolved in 20 cm3 of anhydrous pyridine, 2 cm3 (0.028 mol) of acetyl chloride are added under nitrogen at 0° C. The mixture is stirred for 2 hours 30 mins at 0° C., and then 48 hours at room temperature. The reaction mixture is then poured onto 50 g of ice. A spatulaful of sodium bicarbonate is added, and the mixture is stirred and then extracted with methylene chloride (3 times 60 cm3).

Provenance & Evidence