反应详情

A solution of 10 g of phosphorus tribromide in 50 ml of benzene is added dropwise over a period of 15 minutes to a stirred mixture of 6.6 g of 2-nonylbenzyl alcohol and 50 ml of benzene. The reaction mixture is heated under reflux for 30 minutes and, after cooling, ice-water and ether are added. The organic phase is separated off, washed with water, dried over sodium sulphate and concentrated by evaporation in vacuo. Chromatographic purification of the residue on silica gel with petroleum ether yields 2-nonylbenzyl bromide in the form of a colourless oil.

1. temperatureThe reaction mixture is heated
2. temperatureunder reflux for 30 minutes
3. temperatureafter cooling
4. customThe organic phase is separated off
5. washwashed with water
6. dry with materialdried over sodium sulphate
7. concentrationconcentrated by evaporation in vacuo
8. customChromatographic purification of the residue on silica gel with petroleum ether