Glycine methyl ester hydrochloride → HCID 13364783, compound

HRID 2231867Notes

Reaction equation

HRID 2231867 reaction equation
[C:1]1(=[O:19])[N:5]([CH2:6][C:7](=O)[CH2:8][CH2:9][C:10](=O)[CH3:11])[C:4](=[O:14])[C:3]2=[CH:15][CH:16]=[CH:17][CH:18]=[C:2]12.Cl.[CH3:21][O:22][C:23](=[O:26])[CH2:24][NH2:25].C([O-])(=O)C.[Na+]>C(O)C>[CH3:21][O:22][C:23]([CH2:24][N:25]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]1[CH2:6][N:5]1[C:4](=[O:14])[C:3]2=[CH:15][CH:16]=[CH:17][CH:18]=[C:2]2[C:1]1=[O:19])=[O:26]

Participants

5

Reactant 3

HCID 122755Glycine methyl ester hydrochlorideHCID 517045Sodium AcetateHCID 123484512-(2,5-Dioxohexyl)-1H-isoindole-1,3(2H)-dione

Product 1

HCID 13364783HCID 13364783, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

11.4 g (0.044 mol) of 6-phthalimido-2,5-hexanedione, 27.6 g ((0.22 mol) of glycine methyl ester hydrochloride and 9.1 g (0.11 mol) of sodium acetate are heated under reflux in ethanol for 16 hours and the mixture is worked up as in Example 1.

Sources & evidence

ORD record
ord-f17e635fb14d4377af4eab767a4352e8
Source dataset
uspto-grants-1988_11
Patent number
US04785010

Reaction notes

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