Acetic Anhydride → HCID 19775724, compound

HRID 2231871Notes

Reaction equation

HRID 2231871 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][CH2:9][C:10]1[NH:11][C:12]([CH3:15])=[CH:13][CH:14]=1>C(Cl)Cl>[C:5]([NH:8][CH2:9][C:10]1[NH:11][C:12]([CH3:15])=[CH:13][CH:14]=1)(=[O:7])[CH3:6]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 20038694HCID 20038694, compound

Product 1

HCID 19775724HCID 19775724, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

6.0 g (0.06 mol) of acetic anhydride in 20 ml of methylene chloride are added dropwise to 6.4 g (0.06 mol) of 2-(amino-methyl)-5-methyl-pyrrole (compare Example 11) in 20 ml of methylene chloride at 10° C. After a reaction time of 2 hours at room temperature, the mixture is concentrated and the residue is chromatographed over a silica gel column.

Workup

  1. concentrationAfter a reaction time of 2 hours at room temperature, the mixture is concentrated
  2. customthe residue is chromatographed over a silica gel column

Sources & evidence

ORD record
ord-65dc50a27d7241e38cef1c94a2164dff
Source dataset
uspto-grants-1988_11
Patent number
US04785010

Reaction notes

Loading…