Glycine methyl ester hydrochloride → HCID 13534386, compound

HRID 2231876Notes

Reaction equation

HRID 2231876 reaction equation
[C:1]1(=[O:20])[N:5]([CH2:6][CH2:7][C:8](=O)[CH2:9][CH2:10][C:11](=O)[CH3:12])[C:4](=[O:15])[C:3]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:2]12.Cl.[CH3:22][O:23][C:24](=[O:27])[CH2:25][NH2:26].C([O-])(=O)C.[Na+]>C(O)=O>[CH3:22][O:23][C:24]([CH2:25][N:26]1[C:11]([CH3:12])=[CH:10][CH:9]=[C:8]1[CH2:7][CH2:6][N:5]1[C:4](=[O:15])[C:3]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:2]2[C:1]1=[O:20])=[O:27]

Participants

5

Reactant 3

HCID 122755Glycine methyl ester hydrochlorideHCID 517045Sodium AcetateHCID 12582902HCID 12582902, compound

Product 1

HCID 13534386HCID 13534386, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

82 g (0.03 mol) of 7-phthalimido-2,5-heptanedione, 5.0 g (0.04 mol) of glycine methyl ester hydrochloride and 3.3 g (0.04 mol) of sodium acetate are stirred in 150 ml of formic acid at 60° C. for 4 hours and the mixture is worked up as in Example 27.

Sources & evidence

ORD record
ord-dc89057f1eb349a68f6d04e43ffad1bf
Source dataset
uspto-grants-1988_11
Patent number
US04785010

Reaction notes

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