Glycine → HCID 13534391, compound

HRID 2231880Notes

Reaction equation

HRID 2231880 reaction equation
[C:1]1(=[O:19])[N:5]([CH2:6][C:7](=O)[CH2:8][CH2:9][C:10](=O)[CH3:11])[C:4](=[O:14])[C:3]2=[CH:15][CH:16]=[CH:17][CH:18]=[C:2]12.[NH2:20][CH2:21][C:22]([OH:24])=[O:23]>C(#N)C>[OH:24][C:22]([CH2:21][N:20]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]1[CH2:6][N:5]1[C:4](=[O:14])[C:3]2=[CH:15][CH:16]=[CH:17][CH:18]=[C:2]2[C:1]1=[O:19])=[O:23]

Participants

4

Reactant 2

HCID 750GlycineHCID 123484512-(2,5-Dioxohexyl)-1H-isoindole-1,3(2H)-dione

Product 1

HCID 13534391HCID 13534391, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

5.2 g (0.02 mol) of 6-phthalimido-2,5-hexanedione and 1.6 g (0.02 mol) of glycine are stirred in 50 ml of acetonitrile at 80° C. for 1 hour. After the mixture has been concentrated, it is extracted under alkaline conditions with methylene chloride and the extract is acidified and extracted again. The resulting product is recrystallised from methanol.

Workup

  1. concentrationAfter the mixture has been concentrated
  2. extractionit is extracted under alkaline conditions with methylene chloride
  3. extractionextracted again
  4. customThe resulting product is recrystallised from methanol

Sources & evidence

ORD record
ord-ba1065cf6488430aaed2f21351f8b992
Source dataset
uspto-grants-1988_11
Patent number
US04785010

Reaction notes

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