HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (+/-)-6-{3-[4-(3-chlorophenyl)-1-piperazinyl]-2-hydroxypropoxy}-7-methoxy-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(3-Chlorophenyl)piperazine | HCID 1355 | — |
| Reactant | 7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one | HCID 19927672 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | (+/-)-6-{3-[4-(3-chlorophenyl)-1-piperazinyl]-2-hydroxypropoxy}-7-methoxy-2H-1-benzopyran-2-one | HCID 19927703 | 85% |
Reaction Steps
Method C (3 d at 40° C.); starting materials: 7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one and 1-(3-chlorophenyl)-piperazine; yield 85%; fusion point 140°-141° C. (from isopropanol). Hydrochloride (×1.7 HCl): method F; yield 88%; fusion point 222°-224° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-b91a1e3e3fe1421f900d222808966d43 |
| Source note | uspto-grants-1995_06 |