Sodium Hydroxide → HCID 53837007, compound

Participants

Reaction Steps

A 0.669 g sample of the methyl ester from Example 20 was saponified with sodium hydroxide using the procedure described in Example 17. The crude acid product was chromatographed on 30 g of silica gel. Elution with 2:1 hexane-ethyl acetate afforded 0.386 g (59.6%) of racemic-6-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-acetic acid as a yellow glass.

Provenance & Evidence