HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminum(III) Chloride → 6-(3-Carbomethoxy-2-methyl-propionyl)-3,4-dihydro-4-methyl-2(1H)-quinazolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 4-Methyl-3,4-dihydro-1H-quinazolin-2-one | HCID 12360757 | — |
| Reactant | Methyl 4-chloro-3-methyl-4-oxobutanoate | HCID 14403282 | — |
| Solvent | Carbon Disulfide | HCID 6348 | — |
| Product | 6-(3-Carbomethoxy-2-methyl-propionyl)-3,4-dihydro-4-methyl-2(1H)-quinazolinone | HCID 14620639 | — |
Reaction Steps
3,4-Dihydro-4-methyl-2(1H)-quinazolinone (3.9 g) is added to a stirred suspension of anhydrous aluminum chloride (16.5 g) in carbon disulfide (120 ml) under nitrogen. 3-Carbomethoxy-2-methyl-propionyl chloride (4 g) is added dropwise to the stirred suspension, which is refluxed for about 17 hours and cooled to RT. The liquid phase is decanted and the residue is treated with ice/H2O (150 ml) and extracted with methylene chloride. The organic extract is dried, filtered, and concentrated in vacuo, affording the desired crude product as an oil, which is used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04785101 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-e8cecfee13244ab8a1409a619f9585da |
| Source note | uspto-grants-1988_11 |