Hydrochloric Acid → HCID 21285205, compound

Participants

Reaction Steps

15.67 g (0.042 M) of 1-(3-chlorophenyl)-3-(acetoxymethyl)-6,7-dimethoxy-isoquinoline (compound of Example 21) are refluxed in 160 ml of an aqueous 5% solution of hydrochloric acid for one hour. The crystals of the end-product are rapidly beginning to form from the initially clear solution. After ice-cooling the reaction mixture is filtered, the product is washed with 3×10 ml of water and dried at 90° to 100° C., giving 15.21 g of a crude product, m.p. 210° to 214° C. The crude product is purified by refluxing in 180 ml of 99.5% ethanol, the suspension is cooled and kept at +5° C. for 10 hours, then it is filtered, washed with 3×5 ml of ethanol and dried. Yield 12.67 g (82.4%), m. p. 219° to 221° C. d.

Provenance & Evidence