Acetic Anhydride → HCID 21285199, compound

Participants

Reaction Steps

421.5 g (1.1 M) of 1-(3,4-dimethoxyphenyl-3-methyl-4-ethyl-6,7-dimethoxy-isoquinoline N-oxide and 1.1 liters of acetic anhydride are refluxed for 2.5 hours, then the solution is evaporated at reduced pressure. The residue is recrystallized first from 1.2 liters of 99% ethanol, then the resulting product (414.5 g, m. p. 115° to 120° C.) is repeatedly recrystallized from one liter of 99% ethanol. Yield 393.7 g (84.1%), m.p. 129° to 131° C.

Provenance & Evidence