Propionic anhydride → HCID 21285200, compound

Participants

Reaction Steps

3.83 g (10 mM) of 1-(3,4-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinoline N-oxide is refluxed with 20 ml of propionic anhydride for 1.5 hours. The solution is evaporated at reduced pressure, the residue is suspended in 100 ml of water, filtered, washed with 3×15 ml of water, dried at reduced pressure at room temperature, recrystallized from 7 ml of 99.5% ethanol, filtered, washed with 3×8 ml of ethanol and dried at 80° to 90° C. Yield 2.70 g (61.5%), m.p. 125° to 127° C.

Provenance & Evidence