Ammonia → (Z)-3-Amino-2-methyl-2-butenoic Acid Ethyl Ester

Participants

Reaction Conditions

Reaction Steps

10 kg ethyl methylacetoacetate and 4 l abs. etanol was mixed in an autoclave and 3.4 kg of liquid ammonia was added. The mixture is stirred and the temperature gradually increased to 80° C. during 4 hrs. This temperature is maintained over night. The temperature is decreased to 40° C. and the excess ammonia is evaporated. Toluene (10 l) is added and the water is separated. The organic layer is dried by evaporation of toluene and alcohol. The yield is quantitative. The product is low melting solid.

Provenance & Evidence