HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sarcosine → 3,4-dihydro-4-methyl-6-bromo-2H-1,4-benzodiazepine-2,5(1H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sarcosine | HCID 1088 | — |
| Reactant | 5-bromo-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione | HCID 10752644 | — |
| Product | 3,4-dihydro-4-methyl-6-bromo-2H-1,4-benzodiazepine-2,5(1H)-dione | HCID 19905112 | — |
Reaction Steps
4.84 g (0.02 mol) of 6-bromoisatoic acid anhydride and 1.78 g (0.02 mol) of sarcosine are finely rubbed together and subsequently heated to 260° under a protective gas for 6 minutes. After cooling, the crude product is chromatographed on silica gel using chloroform/methanol (20:1) for the elution. After recrystallization from chloforom/hexane, there is obtained 6-bromo-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione of melting point 232°-233°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04352817 |
| Source dataset | uspto-grants-1982_10 |
| ORD ID | ord-0d489908d86a4758aa29ceb321b10521 |
| Source note | uspto-grants-1982_10 |