Carbon Dioxide → HCID 19851597, compound

HRID 223198Notes

Reaction equation

HRID 223198 reaction equation
[Cl:1][C:2]1[C:7]2[C:8](=[O:20])[N:9]([CH3:19])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][C:15]=3C(O)=O)[C:6]=2[CH:5]=[CH:4][CH:3]=1.C(=O)=O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:7]2[C:8](=[O:20])[N:9]([CH3:19])[CH2:10][C:11]3[N:12]([CH:13]=[N:14][CH:15]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 280Carbon DioxideHCID 145904217-chloro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid

Product 1

HCID 19851597HCID 19851597, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2.69 g of 7-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid are heated to 290°. After completion of the carbon dioxide evolution, the brown melt is cooled and taken up in chloroform. This solution is filtered over a silica gel column and evaporated. There is obtained 7-chloro-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one of melting point 200°-201°.

Workup

  1. filtrationThis solution is filtered over a silica gel column
  2. customevaporated

Sources & evidence

ORD record
ord-5d7bfbf49b734ae898964cf7bb98911d
Source dataset
uspto-grants-1982_10
Patent number
US04352818

Reaction notes

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