HuagongsheHuagongshe Chemistry Print Report · For research reference only
4H-pyran-4-one → 1-(2,2,2-Trifluoroethyl)pyridin-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4H-pyran-4-one | HCID 7968 | — |
| Reactant | 2,2,2-Trifluoroethylamine hydrochloride | HCID 9772 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-(2,2,2-Trifluoroethyl)pyridin-4(1H)-one | HCID 21285111 | 92.3% |
Reaction Steps
1 g (10.4 mmol) of 4H-pyran-4-on was dissolved in 10 ml of pyridine, 3.38 g (25 mmol) of 2,2,2-trifluoroethylamine hydrochloride was added, and reacted at 70° C. for an hour. The solvent was removed, and the residue was purified by chloroform-methanol (10:1) silica gel chromatograph to obtain 1.7 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04785090 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-4b15e66ba38b425c8e53af11fb165301 |
| Source note | uspto-grants-1988_11 |