4H-pyran-4-one → HCID 14651887, compound

HRID 2231983Notes

Reaction equation

HRID 2231983 reaction equation
O1[CH:6]=[CH:5][C:4](=[O:7])[CH:3]=[CH:2]1.Cl.[F:9][CH2:10][CH2:11][NH2:12]>N1C=CC=CC=1>[F:9][CH2:10][CH2:11][N:12]1[CH:6]=[CH:5][C:4](=[O:7])[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 79684H-pyran-4-oneHCID 9995Ethanamine, 2-fluoro-, hydrochloride

Product 1

HCID 14651887HCID 14651887, compoundYield 88.6%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

500 mg (5.2 mmol) of 4H-pyran-4-on was dissolved in 5 ml of pyridine, 1.54 g (15.5 mmol) of 2-fluoroethylamine hydrochloride was added, and reacted at 70° C. for 4 hours. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel chromatography (chlroform-methanol (10:1)) to obtain 650 mg of the title compound.

Workup

  1. customreacted at 70° C. for 4 hours
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe residue was purified by silica gel chromatography (chlroform-methanol (10:1))

Sources & evidence

ORD record
ord-5187736942aa42fc9d1379a0833d5513
Source dataset
uspto-grants-1988_11
Patent number
US04785090

Reaction notes

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