Trifluoroacetic acid → HCID 88519921, compound

Participants

Reaction Steps

2.3 g of the (6R,7R)-7-[(Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-tritylaminothiazol-4-yl)methoxyimino]acetamido]-3-(acetoxymethyl)-ceph-3-em-4-carboxylic acid t-butyl ester was suspended in 2.1 ml of anisole, 21 ml of trifluoroacetic acid was added with ice cooling, and reacted at the same temperature for about 3 hours. After the completion of the reaction, the reaction mixture was poured into 200 ml of isopropyl ether with ice cooling, and the supernatant was removed. The residue was washed thoroughly with isopropyl ether, and the precipitates were filtered off to obtain 1.4 g of (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-[(2-aminothiazol-4-yl)methoxyimino]acetamido]-3-(acetoxymethyl)-ceph-3-em-4-carboxylic acid trifluoroacetate.

Provenance & Evidence