Hydrochloric Acid → HCID 13986129, compound

Participants

Reaction Steps

1.3 g (3.9 mmol) of ethyl 2-(N-formyl-2-ethyl-6-trifluoromethylanilino)-3-hydroxyacrylate were heated for 4 hours at 150° C. with 20 ml of formamide and 5 ml of concentrated hydrochloric acid. After cooling, the mixture was extracted twice with diisopropyl ether, and the organic phase was washed with water, dried over sodium sulfate and evaporated. After chromatographic purification, 0.7 g (57% of theory) of ethyl 1-(2-ethyl-6-trifluoromethylphenyl)imidazole-5-carboxylate, a colorless oil, was obtained. The compound was identified by NMR spectroscopy.

Provenance & Evidence