HCID 14091165, compound → HCID 14278791, compound

Participants

Reaction Steps

A stirred mixture of sodium cyanamide (0.16 g, 2.5 mmol) and anhydrous DMF (3 mL) under a nitrogen atmosphere was treated with solution of 2-chloro-5-[2-(trifluoromethyl)phenyl]-1,3,4-thiadiazole (0.27 g, 1 mmol) in anhydrous DMF (2 mL). The mixture was stirred for 16 h at room temperature. Solvent was removed in vacuo and the residue was stirred with water (10 mL) during the addition of aqueous 2N HCl until the pH was 2. Extraction with Et2O followed by drying of the extracts and evaporation gave the desired cyanamide: yield 0.22 g (82%); MS 270 (M+)(C10H5F3N4S requires M+ 270). The product was used directly without further purification.

Provenance & Evidence