HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 2-(2-Pyridyl)thiazolo[3,2-a]benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | HCID 178418496 | HCID 178418496 | — |
| Product | 2-(2-Pyridyl)thiazolo[3,2-a]benzimidazole | HCID 14391786 | 37.5% |
Reaction Steps
A solution of 2-mercapto-1-[2-oxo-2-(2-pyridyl)ethyl]benzimidazole (1 g.) in polyphosphoric acid was heated at 140° C. for 1 hour. The solution was neutralised with Na2CO3 solution and extracted into EtOAc (700 ml). The extracts were dried (MgSO4) and evaporated to give a solid which was recrystallised from EtOAc/EtOH to give the title compound (0.35 g.) mp 222°-4° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04786636 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-3755b4504c1f4712b9fd4451aa232c60 |
| Source note | uspto-grants-1988_11 |