Triphenylphosphine → HCID 14098951, compound

Participants

Reaction Steps

To a solution of (-)-3,4-dihydro-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (6.3 g), which was prepared by the process (ii), in anhydrous tetrahydrofuran (70 ml), 3-bromo-1-propanol (8.8 g), triphenylphosphine (16.6 g) and then diethyl azodicarboxylate (10.0 ml) were added. The mixture was stirred for 2 hours under nitrogen atmosphere and concentrated in vacuo. The residue was purified by the silica gel column chromatography to give 4.5 g (51%) of (-)-3,4-dihydro-2-[2-(3-bromopropoxy)-5-methoxyphenyl]-4-methyl-3-oxo-2H-1,4-benzothiazine.

Provenance & Evidence