HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiophene → Ethyl 2-(2-bromo-4,5-difluorobenzoyl)-3-(2-thienyl)acrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiophene | HCID 97373 | — |
| Reactant | Ethyl 2-(2-bromo-4,5-difluorobenzoyl)-3-ethoxyacrylate | HCID 54231265 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-(2-bromo-4,5-difluorobenzoyl)-3-(2-thienyl)acrylate | HCID 54013434 | 74.1% |
Reaction Steps
To a solution of ethyl 2-(2-bromo-4,5-difluorobenzoyl)-3-ethoxyacrylate (1.1 g) in ethanol (10 ml) is added portionwise 2-aminothiophene (0.3 g). After stirring the mixture at room temperature for 30 minutes, the precipitated crystals are separated by filtration to give ethyl 2-(2-bromo-4,5-difluorobenzoyl)-3-(2-thienyl)acrylate (0.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04786649 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-34bcd9e5b6644ed7a25647359f605edf |
| Source note | uspto-grants-1988_11 |