HCID 13959887, compound → HCID 14050839, compound

Participants

Reaction Conditions

Reaction Steps

6,7-Difluoro-1-(2-thienyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.5 g) and 3-acetylaminomethyl-4-chloropyrrolidine (0.86 g) are added to N-methylpyrrolidone (50 ml) and the mixture is stirred at 110° C. for one hour. After the reaction, the solvent is distilled off and the resulting residue is crystallized with ethanol. The crystals are separated by filtration and then recrystallized from ethanol to give 6-fluoro-1-(2-thienyl)7-(3-acetylaminomethyl-4-chloro-1-pyrrolidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.54 g) powder, m.p. 145° C. (decomp.).

Provenance & Evidence