Acetyl chloride → 3-Acetylaminomethyl-1-benzyl-4-chloropyrrolidine

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Reaction Steps

To 3-aminomethyl-1-benzyl-4-chloropyrrolidine (2.69 g) is added ethanol (50 ml) and thereto is added dropwise acetyl chloride (1.02 g) with stirring under ice-cooling. The mixture is stirred at room temperature overnight, then concentrated, neutralized with saturated aqueous sodium hydrogen carbonate, and extructed with dichloromethane. The dichloromethane layer is dried and concentrated to give 3-acetylaminomethyl-1-benzyl-4-chloropyrrolidine (2.50 g) as an yellow oil.

Provenance & Evidence