3-Pyridinecarboxaldehyde → HCID 3055794, compound

Participants

Reaction Steps

3-Pyridinecarboxaldehyde (10.7 100 mmol) and ethoxyamine, hydrochloride (10 g, 102.5 mmol) were dissolved in CH3OH (100 ml) and heated at reflux for three hours. The solvent was removed under vacuum and 10% aqueous Na2CO3 solution was added to the residue until the solution remained basic. The aqueous solution was extracted with EtOAc (3×100 ml), dried over MgSO4, filtered, and the solvent removed under vacuum. 13.2 g of 3-pyridinecarboxaldehyde-O-ethyloxime as a clear liquid was obtained 88% yield.

Provenance & Evidence