Carbon Dioxide → 4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one

HRID 223212Notes

Reaction equation

HRID 223212 reaction equation
[CH3:1][N:2]1[C:8](=[O:9])[C:7]2[CH:10]=[CH:11][CH:12]=[CH:13][C:6]=2[N:5]2[CH:14]=[N:15][C:16](C(O)=O)=[C:4]2[CH2:3]1.C(=O)=O>>[CH3:1][N:2]1[C:8](=[O:9])[C:7]2[CH:10]=[CH:11][CH:12]=[CH:13][C:6]=2[N:5]2[CH:14]=[N:15][CH:16]=[C:4]2[CH2:3]1

Participants

3

Reactant 2

HCID 280Carbon DioxideHCID 103326765-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid

Product 1

HCID 199051164,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one

Procedure

8.2 g of 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid are heated to 300°. After completion of the carbon dioxide evolution, the residue is left to cool and the material is recrystallized from chloroform/hexane. After drying, there is obtained 4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one of melting point 212°-213°.

Workup

  1. temperatureto cool
  2. customthe material is recrystallized from chloroform/hexane
  3. customAfter drying

Sources & evidence

ORD record
ord-1489a3cc37bd4b088889158b4c074bcc
Source dataset
uspto-grants-1982_10
Patent number
US04352818

Reaction notes

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