Pyridine, 3-(4-aminobutyl)- → HCID 15017988, compound

Participants

Reaction Steps

As in Example 141, (R)-2,2-diphenylcyclopropanepropanoic acid 4-nitrophenyl ester (4.8 g) was treated with 3-pyridinebutanamine (1.88 g) in tetrahydrofuran (110 mL) at 25° C. for 2 hours. The crude product, isolated in the normal manner, was purified by HPLC (ethyl acetate-hexane; 9:1) and lyophilized from benzene to give 4.3 g of (R)-2,2-diphenyl-N-[4-(3-pyridinyl)butyl]cyclopropanepropanamide as an oil, [α]D25 +86.4° (c, 1.0, MeOH).

Provenance & Evidence