反应详情

12.5 ml (0.13 mol) of acetic anhydride and 4.5 ml (0.105 mol) of 98 percent strength nitric acid are added in succession to 34.1 g (0.10 mol) of 5-acetamido-1-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pyrazole in 85 ml of glacial acetic acid at about 15° C. The temperature is allowed to rise slowly to 25° C. and the mixture is subsequently stirred for 4 hours. The reaction solution is then poured onto 250 ml of water. The precipitate is filtered off, washed neutral and dried in vacuo. 36.3 g (94% of theory) of 5-acetamido-4-nitro-1-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pyrazole of melting point 138° C.-140° C. are obtained.

1. customto rise slowly to 25° C.
2. filtrationThe precipitate is filtered off
3. washwashed neutral
4. customdried in vacuo