Thionyl Chloride → HCID 20523292, compound

Participants

Reaction Steps

6 g (24.6 mmol) of 4,5-dihydro-3-(hydroxymethyl)-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one and 4.45 g of thionyl chloride are heated to boiling under reflux for 2 hours in 50 ml of benzene. The mixture is evaporated to dryness, the residue is taken up in chloroform and washed with 2 N sodium hydroxide. The organic phase is dried over magnesium sulphate and, after removal of the solvent, there is obtained 3-(chloromethyl)-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one of melting point 277°-280°.

Provenance & Evidence