Sulfuryl chloride → HCID 13933714, compound

HRID 2232181Notes

Reaction equation

HRID 2232181 reaction equation
S(Cl)([Cl:4])(=O)=O.[Cl:6][CH:7]([Cl:30])[C:8]([NH:10][C:11]1[N:15]([C:16]2[C:21]([F:22])=[C:20]([F:23])[C:19]([C:24]([F:27])([F:26])[F:25])=[C:18]([F:28])[C:17]=2[F:29])[N:14]=[CH:13][CH:12]=1)=[O:9]>C(Cl)Cl>[Cl:4][C:12]1[CH:13]=[N:14][N:15]([C:16]2[C:17]([F:29])=[C:18]([F:28])[C:19]([C:24]([F:27])([F:26])[F:25])=[C:20]([F:23])[C:21]=2[F:22])[C:11]=1[NH:10][C:8](=[O:9])[CH:7]([Cl:6])[Cl:30]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 13933710HCID 13933710, compound

Product 1

HCID 13933714HCID 13933714, compoundYield 87.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent3×

Procedure

0.9 ml (0.011 mol) of sulphuryl chloride in 5 ml of methylene chloride are added dropwise to a solution of 4.1 g (0.01 mol) of 5-dichloroacetamido-1-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pyrazole in 20 ml of methylene chloride at 0° C.-5° C. The mixture is stirred at room temperature for 16 hours and diluted with 30 ml of methylene chloride, the solution is washed with saturated sodium bicarbonate solution and sodium chloride solution in succession and dried over magnesium sulphate and the solvent is removed in vacuo. 3.9 g (87.2% of theory) of 4-chloro-5-dichloroacetamido-1-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pyrazole of melting point 115° C.-116° C. are obtained.

Workup

  1. washthe solution is washed with saturated sodium bicarbonate solution and sodium chloride solution in succession
  2. dry with materialdried over magnesium sulphate
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-4414f3175eae4a0898a1ecb9e6232315
Source dataset
uspto-grants-1988_11
Patent number
US04787930

Reaction notes

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