Nitric Acid → HCID 13933716, compound

HRID 2232182Notes

Reaction equation

HRID 2232182 reaction equation
C(OC(=O)C)(=O)C.[N+:8]([O-:11])(O)=[O:9].[CH3:12][S:13]([NH:16][C:17]1[N:21]([C:22]2[C:27]([F:28])=[C:26]([F:29])[C:25]([C:30]([F:33])([F:32])[F:31])=[C:24]([F:34])[C:23]=2[F:35])[N:20]=[CH:19][CH:18]=1)(=[O:15])=[O:14].O>C(O)(=O)C>[CH3:12][S:13]([NH:16][C:17]1[N:21]([C:22]2[C:23]([F:35])=[C:24]([F:34])[C:25]([C:30]([F:33])([F:32])[F:31])=[C:26]([F:29])[C:27]=2[F:28])[N:20]=[CH:19][C:18]=1[N+:8]([O-:11])=[O:9])(=[O:14])=[O:15]

Participants

6

Reactant 4

HCID 944Nitric AcidHCID 962WaterHCID 7918Acetic AnhydrideHCID 13933715HCID 13933715, compound

Product 1

HCID 13933716HCID 13933716, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1.07 ml (0.011 mol) of acetic anhydride and 0.45 ml (0.0106 mol) of 98 percent strength nitric acid are added in succession to a solution of 3.8 g (0.01 mol) of 5-methanesulphonamido-1-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pyrazole in 20 ml of glacial acetic acid at about 15° C. The mixture is stirred at room temperature for 16 hours and the reaction solution is poured onto 100 ml of water. The precipitate is filtered off with suction, washed neutral and dried in vacuo. 3.4 g (80% of theory) of 5-methanesulphonamido-4-nitro-1-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pyrazole of melting point 163° C.-168° C. are obtained.

Workup

  1. filtrationThe precipitate is filtered off with suction
  2. washwashed neutral
  3. customdried in vacuo

Sources & evidence

ORD record
ord-34fc9629b2934525b334f9356f373bcf
Source dataset
uspto-grants-1988_11
Patent number
US04787930

Reaction notes

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