Azacytidine → HCID 14329828, compound

Participants

Reaction Steps

To a solution of 5-azacytidine (2.20 g, 9 mmol) in dry pyridine (45 mL) was added 4,4'-dimethoxytrityl chloride (3.15 g, 9.3 mmol) and the mixture was stirred overnight. The reaction mixture was poured into ice-water and extracted with chloroform. The combined organic extracts were dried (MgSO4) and chromatographed through a silica gel column (ethyl acetate--10% methanol/ethyl acetate) to give 2.89 g (59%) of a white product. NMR (CDCl3 +D2O); δ 3.35 (m, 2H), 3.70 (s, 6H), 4.26 (m, 3H), 5.80 (d, 1H), 6.80 (m, 4H), 7.31 (m, 9H), 8.45 (s, 1H).

Provenance & Evidence