Ethyl orthoformate → 1,2,4-Triazolo(3,4-a)phthalazine, 6-phenyl-

HRID 2232227Notes

Reaction equation

HRID 2232227 reaction equation
[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([NH:17][NH2:18])=[N:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:19](OC(OCC)OCC)C>>[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]3=[N:17][N:18]=[CH:19][N:9]3[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 1131691-hydrazinyl-4-phenylphthalazine

Product 1

HCID 973381,2,4-Triazolo(3,4-a)phthalazine, 6-phenyl-

Procedure

A mixture of 4-phenyl-1-hydrazinophthalazine (30 g) and triethylorthoformate (200 ml) is refluxed for 3 hours, then the excess of the orthoformate is evaporated off and the residue is crystallized from ethanol yielding 26 g of the compound of the title. M.p. 198°-99° C.

Workup

  1. temperatureis refluxed for 3 hours
  2. customthe excess of the orthoformate is evaporated off
  3. customthe residue is crystallized from ethanol yielding 26 g of the compound of the title

Sources & evidence

ORD record
ord-59953c45a91f4f99a02b5780bdfaef91
Source dataset
uspto-grants-1988_11
Patent number
US04788186

Reaction notes

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