Acetohydrazide → 1,2,4-Triazolo(3,4-a)phthalazine, 8-chloro-3-methyl-6-phenyl-

HRID 2232229Notes

Reaction equation

HRID 2232229 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[C:5]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:4][N:3]=1.[C:19]([NH:22][NH2:23])(=O)[CH3:20]>C(O)CCC>[Cl:12][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][CH:9]=1)[C:2]1=[N:23][N:22]=[C:19]([CH3:20])[N:3]1[N:4]=[C:5]2[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 21283343HCID 21283343, compound

Product 1

HCID 30712401,2,4-Triazolo(3,4-a)phthalazine, 8-chloro-3-methyl-6-phenyl-

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 1,6-dichloro-4-phenyl-phthalazine (8 g), acetyl hydrazine (4.4 g) and butanol (100 ml) is refluxed for 25 hours. Then the solvent is evaporated off and the residue is washed carefully with a small amount of water and crystallized from ethanol yielding 6 g of the compound of the title. M.p. 236°-38° C.

Workup

  1. temperatureis refluxed for 25 hours
  2. customThen the solvent is evaporated off
  3. washthe residue is washed carefully with a small amount of water
  4. customcrystallized from ethanol yielding 6 g of the compound of the title

Sources & evidence

ORD record
ord-74bb7c420a194442b4c596f9c5054759
Source dataset
uspto-grants-1988_11
Patent number
US04788186

Reaction notes

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